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Requires Refrigeration

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Mutaflor® is a probiotic that comprises as its active substance a viable non-pathogenic strain of Escherichia coli (E.coli). First isolated in 1917 by Professor Alfred Nissle from the faeces of a soldier during the First World War who as he remarked, “in contrast to the large majority of his comrades, had suffered neither from dysentery nor from any other intestinal diseases”. Thereafter, appropriately named Escherichia coli strain Nissle 1917.

Mutaflor® is registered in Australia at AUST R level for the relief and management of chronic constipation. Your healthcare practitioner may also wish to utilise this strain for its pharmacological and metabolic properties.

Characteristics of Escherichia coli strain Nissle 1917.

  • the ability to colonize
  • antagonistic activity – inhibition of growth and or killing of pathogens
  • anti-invasive – prevention of colonisation in the gut by pathogens
  • synthesis of endogenous antimicrobial peptides-defensins
  • mucosal integrity – contributing to luminal metabolism and stability of intestinal milieu-enhanced epithelial barrier function
  • anti-inflammatory and immunomodulatory effects
  • stimulation of colonic mucosa

The therapeutic effects of Mutaflor® are strain specific and have been demonstrated by in-vitro and in-vivo experiments and clinical studies. Mutaflor® Escherichia coli strain Nissle 1917 (EcN) is arguably one of the best studied and field tested probiotic strains and fulfills all the demanding criteria and characteristics required for a medicinal probiotic.

Mutaflor® capsules are enteric coated, reddish brown in colour and cannot be pulled apart. This colouring is part of the enteric coating and ensures that the capsule will not degrade and open until the start of the large intestine is reached. The capsule contents are a beige powder.


Mutaflor® is a probiotic that comprises as its active ingredient a viable non-pathogenic strain of Escherichia coli (E.coli).
Escherichia coli strain Nissle 1917

A Patient Information Leaflet (PIL) accompanies every pack and contains important information relating to the safe use of this product and lists all excipients.


Always read the label and follow the directions for use. Use only as directed.

Images may differ in appearance from the actual product.

All orders are subject to availability. Whilst we endeavour to keep our stock levels accurate, some products may not be immediately available. If an item is purchased that is not available in a reasonable time frame, we will contact you to inform you of excess delays or to discuss alternative product options. 




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We are an Australian company with a distinct difference in probiotics.

Europe has long been the source of Evidence Based Probiotics – and many Australian manufacturers source their active ingredients there.

We supply the actual finished product – not the raw material – to Australia and in doing so, Patients and Healthcare Practitioners are assured the strains are the ones used in the clinical and pharmacological studies to support their use.

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